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Dimethyl sulfoxide is a dipolar, aprotic solvent. Has been shown to accelerate strand renaturation (1-10% concentration) and is believed to give the nucleic acid thermal stability against depurination. Dimethyl sulfoxide is used to enhance dermal absorption of many chemicals. A solvent for many organic and inorganic compounds including fats, carbohydrates, dyes, resins, and polymers. Used in antifreeze or hydraulic fluids and as a cry preservative for cell cultures. Used in the oxidation of thiols and disulfides to sulfonic acids. Used as a PCR solvent to help improve yields, especially in long PCR.
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